Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

JOURNAL ARTICLE published 29 August 2012 in Science Translational Medicine

Authors: Max Jan | Thomas M. Snyder | M. Ryan Corces-Zimmerman | Paresh Vyas | Irving L. Weissman | Stephen R. Quake | Ravindra Majeti

The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

JOURNAL ARTICLE published November 2023 in Science Translational Medicine

Authors: Francesco Trepiccione | Anna Iervolino | Mariavittoria D’Acierno | Sabrina Siccardi | Vincenzo Costanzo | Donato Sardella | Luigi R. De La Motte | Luciano D’Apolito | Antonio Miele | Alessandra F. Perna | Giovanna Capolongo | Miriam Zacchia | Sebastian Frische | Rikke Nielsen | Leopoldo Staiano | Irene Sambri | Rossella De Cegli | Robert Unwin | Dominique Eladari | Giovambattista Capasso

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer

JOURNAL ARTICLE published September 2021 in Science Translational Medicine

Authors: Pınar Özden Eser | Raymond M. Paranal | Jieun Son | Elena Ivanova | Yanan Kuang | Heidi M. Haikala | Ciric To | Jeffrey J. Okoro | Kshiti H. Dholakia | Jihyun Choi | Yoonji Eum | Atsuko Ogino | Pavlos Missios | Dalia Ercan | Man Xu | Michael J. Poitras | Stephen Wang | Kenneth Ngo | Michael Dills | Masahiko Yanagita | Timothy Lopez | Mika Lin | Jeanelle Tsai | Nicolas Floch | Emily S. Chambers | Jennifer Heng | Rana Anjum | Alison D. Santucci | Kesi Michael | Alwin G. Schuller | Darren Cross | Paul D. Smith | Geoffrey R. Oxnard | David A. Barbie | Lynette M. Sholl | Magda Bahcall | Sangeetha Palakurthi | Prafulla C. Gokhale | Cloud P. Paweletz | George Q. Daley | Pasi A. Jänne

Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

JOURNAL ARTICLE published 22 September 2021 in Science Translational Medicine

Authors: Arwa Kohela | Sebastiaan J. van Kampen | Tara Moens | Martijn Wehrens | Bas Molenaar | Cornelis J. Boogerd | Jantine Monshouwer-Kloots | Ilaria Perini | Marie José Goumans | Anke M. Smits | J. Peter van Tintelen | Eva van Rooij

A risk model for digital breast tomosynthesis to predict breast cancer and guide clinical care

JOURNAL ARTICLE published 11 May 2022 in Science Translational Medicine

Authors: Mikael Eriksson | Stamatia Destounis | Kamila Czene | Andrew Zeiberg | Robert Day | Emily F. Conant | Kathy Schilling | Per Hall

Muse cell spheroids have therapeutic effect on corneal scarring wound in mice and tree shrews

JOURNAL ARTICLE published 23 September 2020 in Science Translational Medicine

Research funded by National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (81871495) | Project funded by China Postdoctoral Science Foundation (2019M663391) | the Special Funds for Major Science and Technology Projects of Guangdong Province (2015B010125007) | Joint Fund of Basic and Applied Basic Research Fund of Guangdong Province (2019A1515110355)

Authors: Yonglong Guo | Yunxia Xue | Peiyuan Wang | Zekai Cui | Jixing Cao | Shiwei Liu | Quan Yu | Qiaolang Zeng | Deliang Zhu | Mengyuan Xie | Jun Zhang | Zhijie Li | Hongwei Liu | Jingxiang Zhong | Jiansu Chen

Response to Comment on “Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model”

JOURNAL ARTICLE published 24 October 2012 in Science Translational Medicine

Authors: Lee E. Goldstein | Ann C. McKee

Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors

JOURNAL ARTICLE published 16 November 2016 in Science Translational Medicine

Research funded by German Research Foundation (CRC1181,TRR1181)

Authors: Daniel F. Ortiz | Jonathan C. Lansing | Laura Rutitzky | Elma Kurtagic | Thomas Prod’homme | Amit Choudhury | Nathaniel Washburn | Naveen Bhatnagar | Christopher Beneduce | Kimberly Holte | Robert Prenovitz | Matthew Child | Jason Killough | Steven Tyler | Julia Brown | Stephanie Nguyen | Inessa Schwab | Maurice Hains | Robin Meccariello | Lynn Markowitz | Jing Wang | Radouane Zouaoui | Allison Simpson | Birgit Schultes | Ishan Capila | Leona Ling | Falk Nimmerjahn | Anthony M. Manning | Carlos J. Bosques

Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma

JOURNAL ARTICLE published 24 October 2018 in Science Translational Medicine

Research funded by National Cancer Institute (4K08CA138912-05) | National Cancer Institute (P30CA016672) | University of Texas MD Anderson Cancer Center (Knowledge Gap Funding)

Authors: Liran Zhou | Hongmei Husted | Todd Moore | Mason Lu | Defeng Deng | Yan Liu | Vijaya Ramachandran | Thiruvengadam Arumugam | Christof Niehrs | Huamin Wang | Paul Chiao | Jianhua Ling | Michael A. Curran | Anirban Maitra | Mien-Chie Hung | Jeffrey E. Lee | Craig D. Logsdon | Rosa F. Hwang

Neoantigen quality, not quantity

JOURNAL ARTICLE published 21 August 2019 in Science Translational Medicine

Research funded by Wellcome (211179/Z/18/Z) | Wellcome (FC001169 FC001202) | Medical Research Council (FC001169, FC001202) | Cancer Research UK (FC001169 FC001202) | Novo Nordisk Fonden (ID16584)

Authors: Nicholas McGranahan | Charles Swanton

Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates

JOURNAL ARTICLE published 27 May 2015 in Science Translational Medicine

Authors: Alexis Courbet | Drew Endy | Eric Renard | Franck Molina | Jérôme Bonnet

A first-in-human study of the fibroblast activation protein–targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors

JOURNAL ARTICLE published 10 May 2023 in Science Translational Medicine

Authors: Ignacio Melero | Tamara Tanos | Mariana Bustamante | Miguel F. Sanmamed | Emiliano Calvo | Irene Moreno | Victor Moreno | Tatiana Hernandez | Maria Martinez Garcia | Alejo Rodriguez-Vida | Josep Tabernero | Analia Azaro | Mariano Ponz-Sarvisé | Iben Spanggaard | Kristoffer Rohrberg | Ernesto Guarin | Eveline Nüesch | Iakov I. Davydov | Chiahuey Ooi | José Duarte | Evelyne Chesne | Christine McIntyre | Maurizio Ceppi | Marta Cañamero | Oliver Krieter

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

JOURNAL ARTICLE published 12 June 2019 in Science Translational Medicine

Authors: Anthony T. Virtue | Sam J. McCright | Jasmine M. Wright | Monica T. Jimenez | Walter K. Mowel | Jonathan J. Kotzin | Leonel Joannas | Megha G. Basavappa | Sean P. Spencer | Megan L. Clark | Stephen H. Eisennagel | Adam Williams | Maayan Levy | Sasikanth Manne | Sarah E. Henrickson | E. John Wherry | Christoph A. Thaiss | Eran Elinav | Jorge Henao-Mejia

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

JOURNAL ARTICLE published 14 August 2019 in Science Translational Medicine

Research funded by National Institutes of Health (R01AG044546) | National Institutes of Health (P01AG003991) | National Institutes of Health (RF1AG053303) | National Institutes of Health (R01AG058501) | National Institutes of Health (R01AG035083)

Authors: Yuetiva Deming | Fabia Filipello | Francesca Cignarella | Claudia Cantoni | Simon Hsu | Robert Mikesell | Zeran Li | Jorge L Del-Aguila | Umber Dube | Fabiana Geraldo Farias | Joseph Bradley | John Budde | Laura Ibanez | Maria Victoria Fernandez | Kaj Blennow | Henrik Zetterberg | Amanda Heslegrave | Per M Johansson | Johan Svensson | Bengt Nellgård | Alberto Lleo | Daniel Alcolea | Jordi Clarimon | Lorena Rami | José Luis Molinuevo | Marc Suárez-Calvet | Estrella Morenas-Rodríguez | Gernot Kleinberger | Michael Ewers | Oscar Harari | Christian Haass | Thomas J Brett | Bruno A. Benitez | Celeste M. Karch | Laura Piccio | Carlos Cruchaga

Advances in clinical MRI technology

JOURNAL ARTICLE published 18 December 2019 in Science Translational Medicine

Authors: Mukesh G. Harisinghani | Aileen O’Shea | Ralph Weissleder

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

JOURNAL ARTICLE published 27 May 2020 in Science Translational Medicine

Research funded by National Institutes of Health (R01 CA112567) | National Institutes of Health (R01 CA184836) | National Institutes of Health (R01 CA208213) | National Institutes of Health (R21 CA223102) | National Institutes of Health (P30 CA016672) | Cancer Prevention and Research Institute of Texas (RP180734) | Australian National Health and Medical Research Council grant (APP1113867)

Authors: Lin Zhang | Jun Yao | Yongkun Wei | Zhifen Zhou | Ping Li | Jingkun Qu | Akosua Badu-Nkansah | Xiangliang Yuan | Yu-Wen Huang | Kazutaka Fukumura | Xizeng Mao | Wei-Chao Chang | Jodi Saunus | Sunil Lakhani | Jason T. Huse | Mien-Chie Hung | Dihua Yu

Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy

JOURNAL ARTICLE published 8 June 2022 in Science Translational Medicine

Authors: Gang Yu | Susmita Chakrabarti | Miroslava Tischenko | Ai-Lan Chen | Zhijie Wang | Hyosuk Cho | Brent A. French | Sathyamangla V. Naga Prasad | Qiuyun Chen | Qing K. Wang

Cancer Nanomedicine: From Drug Delivery to Imaging

JOURNAL ARTICLE published 18 December 2013 in Science Translational Medicine

Authors: Edward Kai-Hua Chow | Dean Ho

Tumor-derived circulating endothelial cell clusters in colorectal cancer

JOURNAL ARTICLE published 29 June 2016 in Science Translational Medicine

Authors: Igor Cima | Say Li Kong | Debarka Sengupta | Iain B. Tan | Wai Min Phyo | Daniel Lee | Min Hu | Ciprian Iliescu | Irina Alexander | Wei Lin Goh | Mehran Rahmani | Nur-Afidah Mohamed Suhaimi | Jess H. Vo | Joyce A. Tai | Joanna H. Tan | Clarinda Chua | Rachel Ten | Wan Jun Lim | Min Hoe Chew | Charlotte A. E. Hauser | Rob M. van Dam | Wei-Yen Lim | Shyam Prabhakar | Bing Lim | Poh Koon Koh | Paul Robson | Jackie Y. Ying | Axel M. Hillmer | Min-Han Tan

Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

JOURNAL ARTICLE published 16 December 2020 in Science Translational Medicine

Research funded by Wellcome (Wellcome Collaborative Award In Science 200181/Z/15/Z) | Wellcome (Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z])

Authors: Filipe B. Rodrigues | Lauren M. Byrne | Rosanna Tortelli | Eileanoir B. Johnson | Peter A. Wijeratne | Marzena Arridge | Enrico De Vita | Naghmeh Ghazaleh | Richard Houghton | Hannah Furby | Daniel C. Alexander | Sarah J. Tabrizi | Scott Schobel | Rachael I. Scahill | Amanda Heslegrave | Henrik Zetterberg | Edward J. Wild